Results
| PMID | 22608312 |
| Gene Name | PLCD1 |
| Condition | Endometriosis |
| Association |
Associated |
| Sex | Female |
| Associated genes | PLCB3, PLCD1, PLCB1, PLCD3 |
| Other associated phenotypes |
Endometriosis |
|
Fertil Steril. 2012 Aug;98(2):410-4. doi: 10.1016/j.fertnstert.2012.04.020. Epub Lo Vasco, Vincenza Rita| Leopizzi, Martina| Chiappetta, Caterina| Businaro, Rita| Polonia, Patrizia| Della Rocca, Carlo| Litta, Pietro Department of Sensitive Organs, Policlinic Umberto I, Sapienza University, Rome, Italy. ritalovasco@hotmail.it OBJECTIVE: To delineate the panel of expression of phosphoinositide-specific phospholipase C (PI-PLC) signaling enzymes in normal endometrium and in endometriosis. DESIGN: Clinical/experimental study. SETTING: University. PATIENT(S): Healthy donor woman and endometriosis-affected woman. INTERVENTION(S): Normal endometrium and endometriosis surgical biopsies were analyzed using gene expression analyses methodology (reverse transcriptase-polymerase chain reaction [PCR], bioanalyses). MAIN OUTCOME MEASURE(S): Gene expression (messenger RNA concentration) measures of 12 PI-PLC enzymes: PI-PLC beta1, PI-PLC beta2, PI-PLC beta3, PI-PLC beta4, PI-PLC gamma1, PI-PLC gamma2, PI-PLC delta1, PI-PLC delta3, PI-PLC delta4, PI-PLC epsilon, PI-PLC eta1, and PI-PLC eta2. RESULT(S): PI-PLC beta1, PI-PLC beta3, PI-PLC delta1, and PI-PLC delta3 enzymes were detected, although differently expressed in normal and endometriosis tissues. CONCLUSION(S): The involvement of PI-PLC enzymes in inflammation and the consistency of susceptible endometriosis loci with PI-PLC genes mapping corroborate the hypothesis that PI signaling might be involved in the pathogenesis of endometriosis. Mesh Terms: Adult| Endometriosis/*enzymology/genetics/pathology| Endometrium/*enzymology/pathology| Female| *Gene Expression Regulation, Enzymologic| Humans| Phosphoinositide Phospholipase C/*biosynthesis/genetics|DA 2012/10/12 06:00 |
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